Deny to be aged

Networks between the nucleolus and age-related pathways 

The nucleolus is supposed as a basic housekeeper: It's responsible for generating ribosomal RNA, which is significant for the synthesis of proteins that are crucial to the vitality of the cell,"

Studies of aging and the nucleolus have been performed in yeast, worms, fruit flies, mice, as well as early data in humans experiencing dietary restriction and exercise. Worms are particularly useful for aging research because they only survive for about a month, so it's possible to squeeze their genomes and see what extends or shortens their longivity. Scientists and researchers have seen that common pathways related to aging eventually affect nucleolar size -- organisms with enlarged nucleoli have smaller lifespans and those with shrunken nucleoli have longer lifespans.

Many of these longevity pathways unite on a nucleolar variable gene called NCL-1. Dietary restriction, slowdown insulin signaling, and other lifespan-extending interventions increase the activity of NCL-1, reducing nucleolar size and the formation of ribosomes. Worms missing NCL-1 receive no age-extending benefits from these therapies. Relatedly, people with diseases such as cancer or progeria that enhanced aging have inflated nucleoli with enlarged ribosome biogenesis. It is still unclear why a small nucleolus can extend lifespan, but it may be linked to matching cellular renewal and repair.

"Within an organism, within diverse tissues, it's for assured that nucleolar dimension can vary quite a bit dependent on the metabolic actions of the cells, so for example, in C. elegans, neurons have very minor nucleoli whereas they are quite large in skin cells or muscle cells. It turns out that neurons in C. elegansmaintain their construction well into old age, whereas muscle cells and skin cells tend to weaken more rapidly in the organism. Thus, even within a creature unalike tissues have different nucleolar size and it may replicate different rates of aging."